Basic Information
VIS ID
TVIS10012524
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1076
Orient
+
Integrated sequence
TGATTGGAAAGTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTACACAATGTGGTTATCCTGCGTTGATGCCTTTGTATGCATGTATT| |CAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATACCTGAACCTTTACCCCGTTGCCCGGCAACGGCCAGGTCTGT
Host Sequence
Chromosome
chr5
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
37957331/37957229 (Hg38)
End
37957331/37957229 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA5A
Nearest miRNA
hsa-mir-10397/Upstream/1809241; hsa-mir-103a-1/Downstream/600273;
Nearest TSS
ENST00000502646/Upstream/3827; ENST00000508853/Downstream/68468;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/116605, chr5-CpG: 104/Downstream/300553
Nearby gene
GDNF(-117549) ; EGFLAM(+301180) ;
Upstream sequence
tctgctccttctatctgtgagaatgtgggcaaactatttaaattctttaaaactgcaatttcctctttcataaaaaaaattgcaattataataacttact
Downstream sequence
taagtacactatgatgtttgcacaatgatgaaatcacctgatgatgcacttctcagaaggtattcccattatcattaagcactcatgactgtaacagttt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate