VISDB Viral Integration Site DataBase

VIS ID

TVIS10012525

Fusion event

HBV-IQGAP2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2170

Orient

+

Integrated sequence

CAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCA| |ACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGG

Chromosome

chr5

Cytoband

q13.3

Reference genome

Start

End

75889910/76594085 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-499a-5p ; hsa-mir-208b-3p ; hsa-mir-208a-3p ; hsa-mir-549a ; hsa-mir-641 ; hsa-mir-3617-5p ; hsa-mir-548e-5p ; hsa-mir-92a-1-5p

Nearest miRNA

hsa-mir-10397/Upstream/3715422; hsa-mir-103a-1/Downstream/6246070;

Nearest TSS

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/189750, chr5-CpG: 111/Downstream/121210

Nearest cancer related gene

IQGAP2(TSG, No orient, 0)

Upstream sequence

gcaaactaacacaggaacagacaattaaacaccgcatgttctcacttaaaagaggcagttgaacattgagaacacatggacacagagaggggactagcac

Downstream sequence

AGGGTGCATGTGCCTGTTGTTTTATTCTTGTGAAATCTTGAACATGTTACTGATGATACATGAAGTACAATTTAAAGTTTGTCTTTTTGCTCTATGCGAA