Basic Information
VIS ID
TVIS10012528
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2152
Orient
+
Integrated sequence
CACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACC| |TAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGA
Host Sequence
Chromosome
chr7
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
53059953/52992260 (Hg38)
End
53059953/52992260 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1183/Upstream/8110460; hsa-mir-10399/Downstream/3963525;
Nearest TSS
ENST00000635602/Upstream/799347; ENST00000408890/Downstream/43382;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/717690, chr7-CpG: 52/Downstream/43322
Nearby gene
COBL(-1675438) ; POM121L12(+43396) ;
Upstream sequence
gaaatccatttttactctctcctcaaaatggggggacacagtgttccagcagtcacacccatcgctgggagaCTGACTGAAAATCCAGTCGCGAGCTATG
Downstream sequence
ataggatgataaaaagcaaagcagaaaaatctaaagaacactggaatttatagcagtcttgtggtactggggaaacaaaTATCAGAGTTTGGGAGGTCCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate