Basic Information
VIS ID
TVIS10012537
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1889
Orient
+
Integrated sequence
CATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGG| |GTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGAT
Host Sequence
Chromosome
chr1
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
121484863/121743065 (Hg38)
End
121484863/121743065 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/4648337; hsa-mir-1182/Downstream/24107522;
Nearest TSS
ENST00000473358/Upstream/162541; ENST00000443018/Downstream/21757447;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/223338, chr1-CpG: 312/Downstream/3342444
Nearby gene
EMBP1(-171177) ;
Upstream sequence
ttccttgtgttgtgtgcattcaactcacagagttgaacgttcccttagacagagcagatttgaaacactctatttgtgcaatttgcaagtgtagatttca
Downstream sequence
agcgctttaaggtcaatggcagaaaaggaaatatcttcgtttcaaaactagacagaatcattcccacaaactgcgttgtgatgtgtttgttcaactcaca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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