Basic Information
VIS ID
TVIS10012544
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
481
Orient
-
Integrated sequence
TGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTC| |TAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACC
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
GRCh37/hg19
Start
83186588/82720905 (Hg38)
End
83186588/82720905 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA1L
Nearest miRNA
hsa-mir-101-1/Upstream/5660703; hsa-mir-11399/Downstream/2412889;
Nearest TSS
ENST00000473358/Upstream/459772; ENST00000419658/Downstream/182278;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/917542, chr1-CpG: 50/Downstream/1139679
Nearby gene
LPHN2(-728481) ; MIR548AP(+1073010) ;
Upstream sequence
gctgtgcagaaactttataacttgatgtgatcccatttgtccatgtttgctttggttgcctgtgcttatgaggtattgctcaagaaatctttgcccagac
Downstream sequence
caatgtcttggagattttccccaatgttttcttgtagcagtttcatagtttgagatcttagatttaagtctttaatccatttttatttgaattttgtata
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate