Basic Information
VIS ID
TVIS10012558
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
390
Orient
+
Integrated sequence
TACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGG| |CGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAG
Host Sequence
Chromosome
chr10
Cytoband
q23.32
Reference genome
GRCh37/hg19
Start
93373773/91614016 (Hg38)
End
93373773/91614016 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA10D
Nearest miRNA
hsa-mir-107/Upstream/2021189; hsa-mir-1287/Downstream/4450299;
Nearest TSS
ENST00000439456/Upstream/129908; ENST00000371627/Downstream/19038;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/203200, chr10-CpG: 49/Downstream/18894
Nearby gene
HECTD2-AS1(-2556) ; PPP1R3C(+14424) ;
Upstream sequence
GGAAGCACCCACTGCCCATCGTTATGACTGTATCCTTTTGTGATATGGAGCATCGATATCTTTTGTTGCTGTGATAGGAAGTTTTTGGCATAGGTGTGGC
Downstream sequence
CTGATCATTGTTTTCAAGCACACTAAACCTAGATGGTGATATAATGGAATTGTTGACACTGTTCCCAAGACAGCAGGATGTCTCCACCCTGGTTTGATGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate