Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10012560
Fusion event
HBV-PPP1R3C integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|
Start
1959
Orient
+
Integrated sequence
TACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTG| |CCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATA
Host Sequence
Chromosome
chr10
Cytoband
q23.32
Reference genome
Start
End
93392917/91633160 (Hg38)
Orient
+
Location type
upstream
Fragile sites / regions
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-107/Upstream/2040333; hsa-mir-1287/Downstream/4431155;
Nearest CpG islands
chr10-CpG: 49/Target, None/Upstream, None/Downstream
Upstream sequence
TGGGAGAGACTGAGGGCCCGGCGCCTAGAGGCCGCTTATCTGCTCCCAAGCACGTGACCCGATCCCTGGGACCAATCGCCGGGCCTCGAGCCCCAGGGCG
Downstream sequence
CGACCAACCAGCGCCCAGCTGGGGCGCCAGCCCTCGCCCCGGCAACGTGATCGCCCCGGGGCGAGACGTGCAGAGAGCTATCTGGGCATCGCGGGGAGGT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.