Basic Information
VIS ID
TVIS10012578
Fusion event
HBV-chr16 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
335
Orient
+
Integrated sequence
CAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCA| |CTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTC
Host Sequence
Chromosome
chr16
Cytoband
q21
Reference genome
GRCh37/hg19
Start
61339297/61305393 (Hg38)
End
61339297/61305393 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/3533041; hsa-mir-11401/Downstream/5896928;
Nearest TSS
ENST00000527434/Upstream/782143; ENST00000562349/Downstream/408665;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/1550225, chr16-CpG: 117/Downstream/729824
Nearby gene
APOOP5(-1550202) ; CDH8(+346618) ;
Upstream sequence
CTCCTCTGTACTTCCCAGCAGGATTTCTTTTCTGCATCTATTTGAATTTTTGATGTGTAAACTCTTCCATAAAATCTTGGGGGTTCTGAGAAGCTCCATA
Downstream sequence
TATCATCATAAGAAATATATTGAAATACCTAGCTTCATAATTATGTTAAAACTGATTTCATCAATGTGATGTCTACTCACAAATTTTTTTTAAAGGGCAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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