Basic Information
VIS ID
TVIS10012590
Fusion event
HBV-ROCK1P1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1818
Orient
+
Integrated sequence
GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT
Host Sequence
Chromosome
chr18
Cytoband
p11.32
Reference genome
GRCh37/hg19
Start
108438/108438 (Hg38)
End
108438/108438 (Hg38)
Orient
+
Location type
upstream
Target gene
ROCK1P1
Nearest miRNA
hsa-mir-1-2/Downstream/3818;
Nearest TSS
ENST00000575820/Upstream/34893; ENST00000580410/Downstream/49945;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/32411, chr18-CpG: 21/Downstream/3871
Upstream sequence
catatgactgcactgatcacccaggtgatataactcttgtctaggctctgcctacagggggcttgtgacatatctctgcactgatcacccaggtgatata
Downstream sequence
actcttctctaggatctgcctacagggtgctttgtgacatatccctgcaatgatcacccaggtgatgtaccacttgtcaaggctctgcctacaggggcat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate