Basic Information
VIS ID
TVIS10012591
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
775
Orient
+
Integrated sequence
AGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACA| |GCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAAAACAAAGAGATGGGGTTACTCTCTAAAT
Host Sequence
Chromosome
chr18
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
64326442/66659205 (Hg38)
End
64326442/66659205 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1-2/Upstream/8208047; hsa-mir-5011/Downstream/422379;
Nearest TSS
ENST00000575820/Upstream/55067; ENST00000581951/Downstream/825761;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/907801, chr18-CpG: 83/Downstream/856795
Nearby gene
CDH19(-55226) ; MIR5011(+422379) ;
Upstream sequence
catatggcattggcattttttggaagttcttaaactaagaattacatttctctaatagatatgggacaattccagttattcattttatcagttgattttg
Downstream sequence
atagcttgtgttactcaaagagtaagtgtttaatttattggcatgcagcttctcatatttcctcACTGTTAAAAGGCCAATATAATATTTCCTTCAAAGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate