Basic Information
VIS ID
TVIS10012594
Fusion event
HBV-LOC105372323 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1823
Orient
-
Integrated sequence
TTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACT| |TTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAA
Host Sequence
Chromosome
chr19
Cytoband
p12
Reference genome
GRCh37/hg19
Start
21788223/21605421 (Hg38)
End
21788223/21605421 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105372323
Nearest miRNA
hsa-mir-10395/Upstream/1206067; hsa-let-7e/Downstream/13517279;
Nearest TSS
ENST00000633603/Upstream/10793; ENST00000596471/Downstream/145291;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/18437, chr19-CpG: 22/Downstream/72569
Nearby gene
ZNF429(-67144) ; ZNF100(+118620) ;
Upstream sequence
tgtgggaagagaagctggctttgcaaagaggcatggacgcaggcgtgaacacagtcacggaaaaggctagtccggacaggagtttgaaagctggccaagg
Downstream sequence
ctagagagagatttatgtgcacggtgcaaaaggaaaggacactagaaggatacacgtcaaaagaataaggagaatgggccgggcatggtggctgacgctt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate