Basic Information
VIS ID
TVIS10012602
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1721
Orient
-
Integrated sequence
GTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTT| |TGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAA
Host Sequence
Chromosome
chr2
Cytoband
p25.1
Reference genome
GRCh37/hg19
Start
7713686/7573555 (Hg38)
End
7713686/7573555 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-7158/Upstream/923116; hsa-mir-10b/Downstream/2619059;
Nearest TSS
ENST00000437798/Upstream/312684; ENST00000417930/Downstream/98691;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/142044, chr2-CpG: 29/Downstream/193644
Nearby gene
LOC100506274(-123305) ; LINC00298(+348870) ;
Upstream sequence
ATAAGAAAAGCTTAGCATAGTTTTCTGTGCTCCAATTAAAAAGAAGAATCTTTTAGAAGAGCTTTCACAAGCTGGATAGCAGCTTCCTCCAATCTGGAAT
Downstream sequence
TGAAGTATGAGTCTCACTTTCACACGTATCCTCAGGCAACAGCATCATTCCCACAACATAAAGACGAATGTAAGACTCTACTGTGTGGGACACACTGCGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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