VISDB Viral Integration Site DataBase

VIS ID

TVIS10012617

Fusion event

HBV-RGS12 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

298

Orient

+

Integrated sequence

TTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGT| |GTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTAT

Chromosome

chr4

Cytoband

p16.3

Reference genome

Start

End

3427527/3425800 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-149-5p ; hsa-mir-138-5p ; hsa-mir-7704 ; hsa-mir-4532 ; hsa-mir-4726-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6840-3p ; hsa-mir-665 ; hsa-mir-4459

Nearest miRNA

hsa-mir-4800/Upstream/1175644; hsa-mir-12113/Downstream/2497475;

Nearest TSS

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/12174, chr4-CpG: 24/Downstream/22123

Upstream sequence

tttggaataggtgtggtgtggtgctgaaaaaaatgtatattctgttgatttggggtggagagttctgtagatgtctattaggtctgcttggtgcagaggt

Downstream sequence

gagggggctgtggcgttggcataggggagagggcgagcggggccagtgcaggggagggggctgtggcgttggcataggggagagggtgagcggggccagt