Basic Information
VIS ID
TVIS10012620
Fusion event
HBV-ADGRL3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1815
Orient
-
Integrated sequence
ACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACC| |ATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACC
Host Sequence
Chromosome
chr4
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
62545759/61680041 (Hg38)
End
62545759/61680041 (Hg38)
Orient
+
Location type
Intronic
Target gene
ADGRL3
miRNAs that regulate target gene
hsa-mir-20a-5p
Nearest miRNA
hsa-mir-12113/Upstream/757357; hsa-mir-1243/Downstream/4596783;
Nearest TSS
ENST00000502981/Upstream/92673; ENST00000508078/Downstream/215700;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/476958, chr4-CpG: 60/Downstream/1669088
Upstream sequence
cccacacaataataatgggagactttaacaccccactgtcaacattagacagatcaatgagacagaaagttaacaaggatacccaggaattgaattcagc
Downstream sequence
TAGTTTGTACCATGAAAATACTACTTGCACTTTAGAATGAGGCTCCTAAGTAAAATACTTTTTTAATTACCTGTATTAGAGAAAATCCTTGTGCTTAATT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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