Basic Information
VIS ID
TVIS10012635
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2465
Orient
+
Integrated sequence
CCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGA| |CTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCA
Host Sequence
Chromosome
chr6
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
36320995/36353218 (Hg38)
End
36320995/36353218 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA6H
Nearest miRNA
hsa-mir-1236/Upstream/688429; hsa-mir-10398/Downstream/269218;
Nearest TSS
ENST00000381078/Upstream/16333; ENST00000411643/Downstream/33613;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/155790, chr6-CpG: 61/Downstream/34282
Nearby gene
C6orf222(-16333) ; ETV7(+1003) ;
Upstream sequence
ttgtcactcaagatctccacttgatgtttaatgaacgactcaaacaaaaatgctcaaaactaaactctacattctccctcaaTACATAAATGTAAACAAT
Downstream sequence
tgtaaaagctaagataaattatgtctgcgtgggtgggctgacagcataaaatttagtattctgttgatttaaagaaagtatctttggcattttagtacat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate