Basic Information
VIS ID
TVIS10012638
Fusion event
HBV-LOC100128317 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1774
Orient
-
Integrated sequence
CTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTA| |CTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTC
Host Sequence
Chromosome
chr7
Cytoband
q21.11
Reference genome
GRCh37/hg19
Start
81277440/81648124 (Hg38)
End
81277440/81648124 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC100128317
Nearest miRNA
hsa-mir-10525/Upstream/5732855; hsa-mir-10399/Downstream/10555891;
Nearest TSS
ENST00000635602/Upstream/460334; ENST00000454066/Downstream/114872;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/36732, chr7-CpG: 161/Downstream/794581
Nearby gene
SEMA3C(-728773) ; HGF(+54004) ;
Upstream sequence
tttccatgtagctgcgcggttttgagtgagtttcttaaccctgagttctagtttgattgcactgtggtctgagagacagtttgttataatttctgttctt
Downstream sequence
tgtcattttacatttgtctaaacccatagaatatataacaccaactatgaactctggtgtaaactatggactttgggaaattaggatgcgtcaatatggc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate