Basic Information
VIS ID
TVIS10012650
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1840
Orient
+
Integrated sequence
GTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAA| |TCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGT
Host Sequence
Chromosome
chrX
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
108297734/109054504 (Hg38)
End
108297734/109054504 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Upstream/2414608; hsa-mir-105-1/Downstream/1000825;
Nearest TSS
ENST00000429181/Upstream/317964; ENST00000372107/Downstream/427568;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/317589, chrX-CpG: 30/Downstream/482321
Nearby gene
IRS4(-318127) ; GUCY2F(+318401) ;
Upstream sequence
cccacacattaataatgggagactttaacaccccactgtcaacattagacagatcaatgaaacagtaagtcaacaaggatactcaggaattgaacgcagc
Downstream sequence
tgaaataccactactctgatcgttttttcactgacccggtgaggcgggggggcgagccctgaggggctctcgcttctggcgccaagcgcccggccgcacg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate