Basic Information
VIS ID
TVIS10012658
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2194
Orient
+
Integrated sequence
CTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCA| |GGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGC
Host Sequence
Chromosome
chr1
Cytoband
q43
Reference genome
GRCh37/hg19
Start
238760741/238597441 (Hg38)
End
238760741/238597441 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/1126250; hsa-mir-3123/Downstream/2534831;
Nearest TSS
ENST00000473358/Upstream/111418; ENST00000481779/Downstream/653377;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/813293, chr1-CpG: 91/Downstream/789514
Nearby gene
LINC01139(-111424) ; CHRM3(+1031632) ;
Upstream sequence
caagcgattctcctgcctcagcctcccaagaagctgggattacaggcgcgtgccaccataccgggctaatttttgtatttttagtagagacggggtttca
Downstream sequence
ccatgttggtcaggctggtctcgagctccagacctcaaacccatccgccttggcctcccaaagtgctgggattacaggcgtgagccaccacacccggcct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate