Basic Information
VIS ID
TVIS10012660
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr1
Cytoband
q43
Reference genome
GRCh37/hg19
Start
239210717/239047417 (Hg38)
End
239210717/239047417 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/1576226; hsa-mir-3123/Downstream/2084855;
Nearest TSS
ENST00000473358/Upstream/561394; ENST00000481779/Downstream/203401;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1263269, chr1-CpG: 91/Downstream/339538
Nearby gene
LINC01139(-561400) ; CHRM3(+581656) ;
Upstream sequence
TCATATTTTATTTGAACCAAGGATTACTAAGTCTAATAATCATTTGAGATCTAGGGATCTAGATCAACCATAAAAGTTATAAAAGTAATGCCCTATGAAT
Downstream sequence
GTGACGTTTTCTTTTCTTCAGGTAGTTTTAGATGAAGACACTCAAGGGATATAAATATCTCCATATTCTGAAAAGTATTCAAGAAGAAATGCTTCATCAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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