VISDB Viral Integration Site DataBase

VIS ID

TVIS10012661

Fusion event

HBV-GREM2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|Polymerase|

Start

1594

Orient

-

Integrated sequence

TTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTC| |ACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCG

Chromosome

chr1

Cytoband

q43

Reference genome

Start

End

240759675/240596375 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-26b-5p ; hsa-mir-8072 ; hsa-mir-4467 ; hsa-mir-3960 ; hsa-mir-6087 ; hsa-mir-500b-3p ; hsa-mir-7845-5p ; hsa-mir-3616-3p ; hsa-mir-6891-3p ; hsa-mir-4670-5p ; hsa-mir-6072 ; hsa-mir-503-5p ; hsa-mir-188-5p ; hsa-mir-1199-3p ; hsa-mir-211-3p

Nearest miRNA

hsa-mir-101-1/Upstream/3125184; hsa-mir-3123/Downstream/535897;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/102955, chr1-CpG: 29/Downstream/226979

Upstream sequence

GATATCCATTATATTTTCCCACAGGAAAAGTTAAGGAAATGCGAAACTATAGAGGAATTACTCAACTTTTCTGTCCTAATGACTATGGACCAAAGGTCAT

Downstream sequence

TCATTGGTGTATGCAATCACCCTATAAAACAAGGTGGCTTgccgggcacggtagttcactcctgtaatcccagcactttgggaggctgaggcaggtggat