Basic Information
VIS ID
TVIS10012662
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1741
Orient
+
Integrated sequence
GCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAG| |TTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAAT
Host Sequence
Chromosome
chr1
Cytoband
p32.3
Reference genome
GRCh37/hg19
Start
53629890/53164218 (Hg38)
End
53629890/53164218 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA1B
Nearest miRNA
hsa-mir-12136/Upstream/1327816; hsa-mir-101-1/Downstream/889861;
Nearest TSS
ENST00000473358/Upstream/21586; ENST00000468572/Downstream/32211;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/71248, chr1-CpG: 53/Downstream/32419
Nearby gene
SLC1A7(-21601) ; CPT2(+32211) ;
Upstream sequence
ggaggctgaggtgggtgaatcacttgaggtcatgaattcgagaccagcctggccaacacgtatttttctctactaaaaatacaaaaattagcttggcatg
Downstream sequence
gtggtgtatgcctgtagtcccagctactcaggagactgaggcagaggaatctcttgaacccgggaggcagaggttgcagtgagccgagaacgcgccactg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate