Basic Information
VIS ID
TVIS10012664
Fusion event
HBV-LOC105378724 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1882
Orient
+
Integrated sequence
CTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGT| |GCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGT
Host Sequence
Chromosome
chr1
Cytoband
p32.3
Reference genome
GRCh37/hg19
Start
53653789/53188117 (Hg38)
End
53653789/53188117 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1B
Target gene
LOC105378724
Nearest miRNA
hsa-mir-12136/Upstream/1351715; hsa-mir-101-1/Downstream/865962;
Nearest TSS
ENST00000473358/Upstream/45485; ENST00000468572/Downstream/8312;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/95147, chr1-CpG: 53/Downstream/8520
Nearby gene
SLC1A7(-45500) ; CPT2(+8312) ;
Upstream sequence
gacctaggctagaaacagggaaagtggtcacaaactattatagtaacccagtcaaggaatgaGACAGATATGAAGGAGGTAGATTTGGCAGGACTTGAAA
Downstream sequence
GACATGGTTCTTGCAATAATTTAAACATTCCCATGTGCACATAGCAGTTTGCAAATTCCTTTCATataacaaacttgagaaggagttagcataagcatta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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