Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10012665
Fusion event
HBV-C8B integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|
Start
2094
Orient
+
Integrated sequence
AGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAA| |CTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCA
Host Sequence
Chromosome
chr1
Cytoband
p32.2
Reference genome
Start
End
57414761/56949088 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
Target gene
Nearest miRNA
hsa-mir-12136/Upstream/1723365; hsa-mir-101-1/Downstream/2784139;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/303524, chr1-CpG: 222/Downstream/473203
Upstream sequence
TCTAAAAAGTAAGTTAGCTATTTTTTTTTTTTGAGAAGATTTCAAGACAACAGAAAGATAATTGGTTGTTAGAACTAGTTGTAACGTGGAATATAGACAC
Downstream sequence
ATTTGGGGCATGTCATTTCCAAAGGATCCATAtgctatatctggaatgtcccctccaaaactcatgttgaaatttaattgccattgtaacagttttgaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.