Basic Information
VIS ID
TVIS10012667
Fusion event
HBV-LDHAP5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1822
Orient
+
Integrated sequence
GTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAAC| |TTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAA
Host Sequence
Chromosome
chr10
Cytoband
q26.11
Reference genome
GRCh37/hg19
Start
120692158/118932646 (Hg38)
End
120692158/118932646 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
LDHAP5
Nearest miRNA
hsa-mir-107/Upstream/1764872; hsa-mir-202/Downstream/445326;
Nearest TSS
ENST00000439456/Upstream/177397; ENST00000340087/Downstream/71238;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/177050, chr10-CpG: 176/Downstream/96631
Nearby gene
CACUL1(-177400) ; NANOS1(+97070) ;
Upstream sequence
CCCAGTCCATCTTAAAATATTACTGCTTTAATCACAGATCAGATAAAAAGGATATCAGGCACAACCTCCAACTAAAGTCCTGTTGTAGCATAGACAGTGA
Downstream sequence
AATGCTATGACATCAGAAGACTTTAAAATTGCAGCTCTTTTCGGATCCCCCAAAGTGTGTCTGCACGCTTCTTCAAACGGGCCTCTTCCTCAGGAGTCAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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