Basic Information
VIS ID
TVIS10012668
Fusion event
HBV-LDHAP5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1731
Orient
-
Integrated sequence
ACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGA| |CTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACC
Host Sequence
Chromosome
chr10
Cytoband
q26.11
Reference genome
GRCh37/hg19
Start
120692161/118932649 (Hg38)
End
120692161/118932649 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
LDHAP5
Nearest miRNA
hsa-mir-107/Upstream/1764875; hsa-mir-202/Downstream/445323;
Nearest TSS
ENST00000439456/Upstream/177400; ENST00000340087/Downstream/71235;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/177053, chr10-CpG: 176/Downstream/96628
Nearby gene
CACUL1(-177403) ; NANOS1(+97067) ;
Upstream sequence
AGTCCATCTTAAAATATTACTGCTTTAATCACAGATCAGATAAAAAGGATATCAGGCACAACCTCCAACTAAAGTCCTGTTGTAGCATAGACAGTGAAAT
Downstream sequence
GCTATGACATCAGAAGACTTTAAAATTGCAGCTCTTTTCGGATCCCCCAAAGTGTGTCTGCACGCTTCTTCAAACGGGCCTCTTCCTCAGGAGTCAGAGT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate