Basic Information
VIS ID
TVIS10012669
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1844
Orient
+
Integrated sequence
GGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCAT| |CTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAG
Host Sequence
Chromosome
chr10
Cytoband
q26.11
Reference genome
GRCh37/hg19
Start
120776120/119016608 (Hg38)
End
120776120/119016608 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Nearest miRNA
hsa-mir-107/Upstream/1848834; hsa-mir-202/Downstream/361364;
Nearest TSS
ENST00000439456/Upstream/12724; ENST00000340087/Downstream/13108;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/261012, chr10-CpG: 176/Downstream/12669
Nearby gene
CACUL1(-261362) ; NANOS1(+13108) ;
Upstream sequence
acagagtgagaccccatctcaagagaaaaaaaagaaaGCTGGACCCAGGGAAAGGATAAAATTAAACCTACCACAGGAGAGCAGGAGAAGGAGTGGGCAG
Downstream sequence
AATTGGATAAAACACTCTGGGGAGCtttcttaacaccgttataaataatattttaatcacattttctgtttgttttgatatattgaaatgcaattcattt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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