Basic Information
VIS ID
TVIS10012670
Fusion event
HBV-FAM45BP integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1820
Orient
-
Integrated sequence
TTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTAT
Host Sequence
Chromosome
chr10
Cytoband
q26.11
Reference genome
GRCh37/hg19
Start
120885125/119125613 (Hg38)
End
120885125/119125613 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA10D ; FRA10F ; FRA10A ; FRA10B
Target gene
FAM45BP
Nearest miRNA
hsa-mir-107/Upstream/1957839; hsa-mir-202/Downstream/252359;
Nearest TSS
ENST00000439456/Upstream/5231; ENST00000462327/Downstream/3862;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/20721, chr10-CpG: 85/Downstream/39660
Upstream sequence
ttttttttttttgagttggagtctcactctgttgcccaggctggagtgcagtggcacgatctcagcatactacggcctccacctcccaggttcaagcgat
Downstream sequence
tctcctgcctcagctgcctgagtagctgggattacaggtgtgcaccaccatgcccagctaatttttttgtatttttggtagagagtagagatggggtttt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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