Basic Information
VIS ID
TVIS10012672
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1881
Orient
+
Integrated sequence
GCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTG| |TGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAG
Host Sequence
Chromosome
chr10
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
72395453/70635697 (Hg38)
End
72395453/70635697 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1265/Upstream/3232287; hsa-mir-107/Downstream/1155050;
Nearest TSS
ENST00000439456/Upstream/32922; ENST00000373208/Downstream/37106;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/34872, chr10-CpG: 48/Downstream/36789
Nearby gene
PRF1(-32922) ; ADAMTS14(+37106) ;
Upstream sequence
gcTAGAAAATCaatttaatcttttaaaaaacaaataaacacacacacacacacacacacacacacacacacacacaaacacaaacacattcctacaaaga
Downstream sequence
taactctaggcctaaaccgtgggtttcatccaaatatttaggggcaatataacattaatcttacctaaaactttccagggaaaacagttccttcatttta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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