Basic Information
VIS ID
TVIS10012677
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1823
Orient
-
Integrated sequence
TTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACT| |TTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAA
Host Sequence
Chromosome
chr12
Cytoband
q13.11
Reference genome
GRCh37/hg19
Start
47066783/46673000 (Hg38)
End
47066783/46673000 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA12A
Nearest miRNA
hsa-mir-1244-3/Upstream/4349141; hsa-let-7i/Downstream/514812;
Nearest TSS
ENST00000382841/Upstream/135498; ENST00000621214/Downstream/96304;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/288927, chr12-CpG: 64/Downstream/158129
Nearby gene
SLC38A2(-300138) ; SLC38A4(+91761) ;
Upstream sequence
ttatatataattctcctcaaaggtatccttatttctaacaccatagattatttttctgtttttgaaatttttataaatagaagtatacaatatataatat
Downstream sequence
gtaattttttttggtctggaatccattgcctgaaatcgtatttttaagagtcaagtgtgttggtgtgacatgtttggctctgtgtacccacccaaatctc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate