VISDB Viral Integration Site DataBase

VIS ID

TVIS10012679

Fusion event

HBV-TMTC2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1820

Orient

+

Integrated sequence

TTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTAT

Chromosome

chr12

Cytoband

q21.31

Reference genome

Start

End

83166662/82772883 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-4470 ; hsa-mir-561-3p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-6734-3p ; hsa-mir-6832-3p ; hsa-mir-6770-5p ; hsa-mir-1253 ; hsa-mir-6761-5p ; hsa-mir-4329 ; hsa-mir-4251

Nearest miRNA

hsa-let-7i/Upstream/1614422; hsa-mir-1178/Downstream/3972185;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/85016, chr12-CpG: 17/Downstream/2138538

Upstream sequence

GTAATTTTACACCTATTTAAATTCTACGTTGGGTGCTTTTTTTCGCTAATGATCTGTGGAAATTATTTTGGTGTTGACACAAATGGGAAAGTAGTGTCGG

Downstream sequence

AGTGGGGGGAGACAGCTCTCTTTCCTAGGTATAAATGAAAAAAGGATAATTATTAATTACTTTAGAAAATTGTCTTTCTACTTCCTTATTTTCAAAGGTT