Basic Information
VIS ID
TVIS10012680
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2220
Orient
-
Integrated sequence
TGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCT| |TGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCC
Host Sequence
Chromosome
chr12
Cytoband
q22
Reference genome
GRCh37/hg19
Start
95138883/94745107 (Hg38)
End
95138883/94745107 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7i/Upstream/173755; hsa-mir-1178/Downstream/89291;
Nearest TSS
ENST00000382841/Upstream/94545; ENST00000551792/Downstream/179699;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/94571, chr12-CpG: 119/Downstream/127949
Nearby gene
TMCC3(-94559) ; MIR492(+89291) ;
Upstream sequence
GCGGGAGGTAATGGGGGTGGGAAGGAAGACAAGGGGAGGGACTGAGGACCCCGAGTTTTAATCTAAGAGGGCTTGGATTTTATTCCATGGGCAAAGGGGA
Downstream sequence
GCTAATGAAGGCTTAAAGCAGCTACAGATGCACCATTTTGCACTTATAATATCTCAAACTCAGTAGTCTTAGGACAAGGTTATTAGTGATCCCCATTTTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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