Basic Information
VIS ID
TVIS10012681
Fusion event
HBV-chr13 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1800
Orient
-
Integrated sequence
AGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGT| |CTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGG
Host Sequence
Chromosome
chr13
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
54215594/53641459 (Hg38)
End
54215594/53641459 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-15a/Upstream/831319; hsa-mir-1267/Downstream/670513;
Nearest TSS
ENST00000623511/Upstream/296248; ENST00000569422/Downstream/173960;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/439249, chr13-CpG: 25/Downstream/3499378
Nearby gene
OLFM4(-589398) ; LINC00558(+173960) ;
Nearest cancer related gene
OLFM4(TSG, -589398) ;
Upstream sequence
TTTGTTATAGGAAAGATGGTggattgagaaagaaaaattttgtctgagagggctctttaattatcaggcccagaaaagtattgacatgcaatactagtca
Downstream sequence
cttcttactccccacttgaggtacatatttacgtcttgaagctactggctatgtgggttctaggctaactgatgccaagtagccataaaattccatacta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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