POMT2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10012685
Fusion event
HBV-POMT2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr14
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
77742164/77275821 (Hg38)
End
77742164/77275821 (Hg38)
Orient
+
Location type
UTR3
Target gene
POMT2
miRNAs that regulate target gene
hsa-mir-146b-5p ; hsa-mir-542-3p ; hsa-mir-219b-3p ; hsa-mir-5190
Nearest miRNA
hsa-mir-1260a/Upstream/9531; hsa-mir-1185-1/Downstream/16672405;
Nearest TSS
ENST00000550708/Upstream/4509; ENST00000553770/Downstream/3240;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/4392, chr14-CpG: 113/Downstream/44526
Upstream sequence
CCGCACAGACAGCGCTTCCTGCTGGGGGAAGTCAAAAGGGCTGTAGCAGTGGGAAAGGGAGGTCATCGGGCCCCAGATCTAATTAACCAACCTGCCTTGC
Downstream sequence
TTTTGACGTTGCTGCATTTCCTCTATTAACATTAATGATGGTTGGTCTGAATGCCCAAGCATGGCCAGAAGCTTCCCTCCCCACCACCCAGTAGGTAGCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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