Basic Information
VIS ID
TVIS10012688
Fusion event
HBV-LOC105371002 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr15
Cytoband
q26.2
Reference genome
GRCh37/hg19
Start
97241304/96698074 (Hg38)
End
97241304/96698074 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105371002
Nearest miRNA
hsa-mir-10393/Upstream/364767; hsa-mir-1302-10/Downstream/2086352;
Nearest TSS
ENST00000557528/Upstream/249232; ENST00000561002/Downstream/83580;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/280773, chr15-CpG: 32/Downstream/954717
Nearby gene
NR2F2(-357812) ; SPATA8(+85375) ;
Upstream sequence
ATTGGAAGAACATGGTAGAAACATCTCTCATTAATCAGACTCTCCATTTCTTTAATTAAAGAATAAATGACTAGCATTTTGCTTCTGCCCTCGGTGAAGG
Downstream sequence
ACTCATAGAAAACCAAATGCCCCCTTTCTGAGTTGGTTGGCCAAGGCTCCTGTTAGTGTTAAGTGTTCACATTGATAACTACAGAATCAGTTCCTTGGGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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