VISDB Viral Integration Site DataBase

VIS ID

TVIS10012690

Fusion event

HBV-MAP2K4 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1765

Orient

-

Integrated sequence

TCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAG| |GTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGT

Chromosome

chr17

Cytoband

p12

Reference genome

Start

End

11983602/12080285 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-375 ; hsa-mir-15b-5p ; hsa-mir-26b-5p ; hsa-mir-25-3p ; hsa-mir-145-5p ; hsa-mir-188-5p ; hsa-mir-27a-3p ; hsa-mir-92a-3p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p ; hsa-mir-542-3p ; hsa-mir-4261 ; hsa-mir-3134 ; hsa-mir-8082 ; hsa-mir-4534 ; hsa-mir-4433a-3p ; hsa-mir-3688-3p ; hsa-mir-6818-3p ; hsa-mir-7855-5p ; hsa-mir-4325 ; hsa-mir-7703 ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-3185 ; hsa-mir-3121-5p ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-3614-5p ; hsa-mir-10a-3p ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-548a-5p ; hsa-mir-363-3p ; hsa-mir-367-3p ; hsa-mir-92b-3p ; hsa-mir-32-5p

Nearest miRNA

hsa-mir-1253/Upstream/3893281; hsa-mir-10226/Downstream/1614;

Nearest TSS

Nearest CpG islands

None/Target, chr17-CpG: 26/Upstream/58731, chr17-CpG: 70/Downstream/585065

Nearest cancer related gene

MAP2K4(TSG, No orient, 0)

Upstream sequence

AAACCATTCTACTAATTGGAGAAAACTTTCCTAAATTTTGGAAGAAGAAAAATAATGACCAAGCACATAAACTTTGCTTGTTTGCATCATAGGATCAGAG

Downstream sequence

TTTAAAAGAGATCCTGATCATTTAGTATGAAACTGAAAAATGTAGTTGATATTTAATGAATTCTTTCATTGTGTGTATGGTTGATAGTTTGTTCCTACAC