Basic Information
VIS ID
TVIS10012696
Fusion event
HBV-chr17 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1253
Orient
-
Integrated sequence
TGCCCGGCAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTTTTCG| |GCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTAT
Host Sequence
Chromosome
chr17
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
61547249/63469888 (Hg38)
End
61547249/63469888 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10226/Upstream/525576; hsa-mir-1250/Downstream/1030886;
Nearest TSS
ENST00000595228/Upstream/14895; ENST00000579462/Downstream/7173;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/22779, chr17-CpG: 91/Downstream/6688
Nearby gene
CYB561(-23527) ; ACE(+7173) ;
Upstream sequence
ttcttgtgatagtgagggagttctcacgagatccaatggttgtttttttgtttgtttgttttctgttttttgtttttttttttttttgagacagagtttc
Downstream sequence
actcgtttcccaggctggagtgcaatggcacaatctcggctcactgcaacctccgcctcccgggttcaagtgattttcctgcctcagtctcccgaatagc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate