VISDB Viral Integration Site DataBase

VIS ID

TVIS10012697

Fusion event

HBV-CELF4 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

1904

Orient

+

Integrated sequence

GCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCAT| |GGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCC

Chromosome

chr18

Cytoband

q12.2

Reference genome

Start

End

35050536/37470573 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-3960 ; hsa-mir-4467 ; hsa-mir-8072 ; hsa-mir-2681-5p ; hsa-mir-378a-3p ; hsa-mir-378b ; hsa-mir-378c ; hsa-mir-378d ; hsa-mir-378e ; hsa-mir-378f ; hsa-mir-378h ; hsa-mir-378i ; hsa-mir-422a ; hsa-mir-4638-3p

Nearest miRNA

hsa-mir-1-2/Upstream/1536431; hsa-mir-122/Downstream/186562;

Nearest TSS

Nearest CpG islands

None/Target, chr18-CpG: 67/Upstream/76072, chr18-CpG: 94/Downstream/14503

Upstream sequence

gtttactTGGTCATCAATCATGGAGCCTTTTCAAGATAAAGGCCATGTTGCAAATGAGAACAGACCCAAATGTGGCATCCCAGCAGCGCTGTGTCCAACT

Downstream sequence

GTCTAGGCAAGTGATGCTTATGTCCCTTCCCACTCCACTTTTCTGAGGTTCTCTGACCCTCAGGAGGGAAACATAATTGCAGAGTGGGGCCCTCCTCATG