Basic Information
VIS ID
TVIS10012700
Fusion event
HBV-SNAR-C3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1873
Orient
+
Integrated sequence
ACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCT| |CCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTT
Host Sequence
Chromosome
chr19
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
48453665/47950408 (Hg38)
End
48453665/47950408 (Hg38)
Orient
+
Location type
ncRNA_exonic
Fragile sites / regions
FRA19A
Target gene
SNAR-C3
Nearest miRNA
hsa-mir-10395/Upstream/723387; hsa-let-7e/Downstream/1059498;
Nearest TSS
ENST00000633603/Upstream/64011; ENST00000596043/Downstream/41762;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/89505, chr19-CpG: 21/Downstream/111404
Upstream sequence
GGCTCCGGCCGGTTGCGCGGGCCCTCGGACCCTCAGAGAGGCGAGGGTTCGAGGGCACGAGTTCGAGGCCAACCTGGTCCACATGGGTTGAAAAAAAAAT
Downstream sequence
TTTTTTATCGTTCCCAATATAACAACAAAACATAAAGGGAGGACGTCTTGATAGGAAGAAATGACATCTTCCTAAGTGTTTTTAAATTACTTCAATGTAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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