Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10012701
Fusion event
HBV-MLPH integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
Polymerase|
Start
2793
Orient
+
Integrated sequence
TTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAAC| |AACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCC
Host Sequence
Chromosome
chr2
Cytoband
q37.3
Reference genome
End
238420733/237512090 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
Target gene
Nearest miRNA
hsa-mir-10b/Upstream/1102; hsa-mir-149/Downstream/1556727;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/24492, chr2-CpG: 124/Downstream/114828
Upstream sequence
CCAAGCATTCGGGTGGGACAGCCGCCACCAAGCCAGGTGTCTGGGGTCTCAGTGTCCTGGATGACTCCATCTGCAAGACCAAGGCGAGTTTCTCCAGGGC
Downstream sequence
CACGAGGCAGCGCCTGGCTCCGGCAGCTGGGCACGTCCAGGGCAGAGGCTGTGCTTCTGGATTGGGGCGTCCTCACCATGCCCCAGCCCAGGCGTCTCCC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.