VISDB Viral Integration Site DataBase

VIS ID

TVIS10012705

Fusion event

HBV-CBFA2T2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

1915

Orient

+

Integrated sequence

ATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACC| |CTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTA

Chromosome

chr20

Cytoband

q11.22

Reference genome

Start

End

32162419/33574613 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-101-3p ; hsa-mir-106b-5p ; hsa-mir-92a-3p ; hsa-mir-7977 ; hsa-mir-7160-5p ; hsa-mir-5690 ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-510-5p ; hsa-mir-512-5p ; hsa-mir-1273g-3p ; hsa-mir-1910-3p ; hsa-mir-2467-3p ; hsa-mir-3202 ; hsa-mir-3714 ; hsa-mir-377-5p ; hsa-mir-4252 ; hsa-mir-4257 ; hsa-mir-4533 ; hsa-mir-455-3p ; hsa-mir-490-3p ; hsa-mir-5694 ; hsa-mir-605-3p ; hsa-mir-6086 ; hsa-mir-619-3p ; hsa-mir-6499-3p ; hsa-mir-6511a-5p ; hsa-mir-6516-5p ; hsa-mir-6807-5p

Nearest miRNA

hsa-mir-103a-2/Upstream/1336766; hsa-mir-1-1/Downstream/474506;

Nearest TSS

Nearest CpG islands

None/Target, chr20-CpG: 39/Upstream/83950, chr20-CpG: 17/Downstream/69751

Upstream sequence

actcgggtggctgaggcaggagaatggcttgaacccgggaggcagaggttgcagtgagccgagattgtgccattgcactccagcctgggaaacgagtgaa

Downstream sequence

actccatctcaaaaaaacaaacaaacaaaaaCTCTTATAAAAAGTTGTTTTCTTTTTAAGCAGGGAAGCCTGACTTCATTGGCATTTTGAGATGGAGGCT