Basic Information
VIS ID
TVIS10012708
Fusion event
HBV-chr21 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3110
Orient
+
Integrated sequence
GGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAAT| |CGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGGCCATGCAGTGG
Host Sequence
Chromosome
chr21
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
23569642/22197323 (Hg38)
End
23569642/22197323 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7c/Upstream/3511159; hsa-mir-155/Downstream/881961;
Nearest TSS
ENST00000624081/Upstream/98706; ENST00000444130/Downstream/12616;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/1199078, chr21-CpG: 28/Downstream/3164471
Nearby gene
LINC00308(-80795) ; D21S2088E(+1163784) ;
Upstream sequence
gcctttattattttgaggcaatttctttttatacaacatttgttagaaattttttttaatcataaaagggcattaaattttgtcatttttttctttctgc
Downstream sequence
atctttaaaatgaccatgtgatttttagcattcattctgttaatgtaatgtatcaaattaactaatgtttatatgttaacacatatttgcatcttgggga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate