TPRG1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10012712
Fusion event
HBV-TPRG1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3198
Orient
+
Integrated sequence
GCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGGCCATGCAGTGG| |
Host Sequence
Chromosome
chr3
Cytoband
q28
Reference genome
GRCh37/hg19
Start
188867547/189149758 (Hg38)
End
188867547/189149758 (Hg38)
Orient
-
Location type
Intronic
Target gene
TPRG1
miRNAs that regulate target gene
hsa-mir-145-5p
Nearest miRNA
hsa-let-7g/Upstream/460892; hsa-mir-3137/Downstream/680164;
Nearest TSS
ENST00000440867/Upstream/17073; ENST00000493725/Downstream/896;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/201995, chr3-CpG: 99/Downstream/970533
Nearby gene
LPP(-259087) ; TPRG1(+22216) ;
Upstream sequence
taaggttatctctcttgttccctgaacattgctgttatcctgttcttttttcaaggtgcccagatttcatattgttcaaacacacatgctctacaatttg
Downstream sequence
GAGCCTGTGTCCGGAACTGCCTCCTTCTTGCCATCTGGTAGCTGACATCTGCCACATCTTTCCAACCAGAGCCCCCATCTTTTCTTGGAGGCCTTTAAAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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