Basic Information
VIS ID
TVIS10012715
Fusion event
HBV-CCSER1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2369
Orient
+
Integrated sequence
GAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCC| |TAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCA
Host Sequence
Chromosome
chr4
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
91676073/90754922 (Hg38)
End
91676073/90754922 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4E
Target gene
CCSER1
miRNAs that regulate target gene
hsa-mir-544a
Nearest miRNA
hsa-mir-12113/Upstream/3454339; hsa-mir-1243/Downstream/8242465;
Nearest TSS
ENST00000502981/Upstream/105402; ENST00000515693/Downstream/60891;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/626391, chr4-CpG: 22/Downstream/83966
Upstream sequence
gatatagtttggttgtgtccccacccaaatcccaccttgaattgtattaatctccacttttcaagcgtggagtcaggtggagataattgaatcatggaga
Downstream sequence
tctgctcccctttcctcatctccagcttctgaattaaagaccccattataatctaatacagctattggagttcctgccatcacatcagtgttccagatag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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