Basic Information
VIS ID
TVIS10012716
Fusion event
HBV-LOC102467217 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2140
Orient
+
Integrated sequence
CATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAG| |CGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGA
Host Sequence
Chromosome
chr5
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
114990019/115654322 (Hg38)
End
114990019/115654322 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC102467217
Nearest miRNA
hsa-mir-10397/Upstream/5140407; hsa-mir-103a-1/Downstream/601421;
Nearest TSS
ENST00000502646/Upstream/21330; ENST00000512900/Downstream/37845;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/28050, chr5-CpG: 122/Downstream/161329
Nearby gene
TMED7-TICAM2(-28143) ; CDO1(+150411) ;
Upstream sequence
CCGCCCGCACAGGGTGGAGGGCAACCTCGGGGTCCAGGCACCTGGCTCCAAGCCTCGGACTGCAGAGCTAGGAGGCCCGACTTCCAGCCCAGCAGTAGAA
Downstream sequence
ttcctatttctcatcctgatcacacttggtttattgatggcagttccaccagggctaattgccactcaccagcaaaggcaggctatactatAGTATTTTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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