Basic Information
VIS ID
TVIS10012719
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1726
Orient
-
Integrated sequence
CGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTT| |AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT
Host Sequence
Chromosome
chr5
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
34992732/34992627 (Hg38)
End
34992732/34992627 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA5A
Nearest miRNA
hsa-mir-10397/Upstream/2598152; hsa-mir-103a-1/Downstream/1155265;
Nearest TSS
ENST00000502646/Upstream/39101; ENST00000505088/Downstream/33206;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/62291, chr5-CpG: 33/Downstream/625126
Nearby gene
DNAJC21(-33663) ; AGXT2(+5474) ;
Upstream sequence
gagacagaaagttaacaaggatacccaggaattgaactcagctctgcaccaagtggacctaatagacatctacagaactctccatcccaaatcaacagaa
Downstream sequence
TGGCTCAAGATGGTGACAACCAAGTGCCAACTAAGGGAGTTTCTGGGTGAAAAGGCAGAGAATCCTAAGGAGAAAGTTATTATTGGAGAAGCTGCCAGTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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