Basic Information
VIS ID
TVIS10012720
Fusion event
HBV-LOC102723831 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr6
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
151528552/151207417 (Hg38)
End
151528552/151207417 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC102723831
Nearest miRNA
hsa-mir-10398/Upstream/104641; hsa-mir-1202/Downstream/3645943;
Nearest TSS
ENST00000381078/Upstream/9779; ENST00000490177/Downstream/21030;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/116214, chr6-CpG: 16/Downstream/32214
Nearby gene
MTHFD1L(-105529) ; AKAP12(+32582) ;
Upstream sequence
atatttaatgtgtacaatttgacatatttggacatatacatatacccataaaaccattacaacaatcgagataatgagtacatcacccccagtagattct
Downstream sequence
cctggctaattttttgtattttttttagtagaggtggggttttgccatgttgggcaggctggtcttgaactcctgacctcagatgatctgctcgccttgg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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