Basic Information
VIS ID
TVIS10012721
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1741
Orient
+
Integrated sequence
GCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAG| |TTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAAT
Host Sequence
Chromosome
chr6
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
30276833/30309056 (Hg38)
End
30276833/30309056 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
HCG17 ; HCG18
Nearest miRNA
hsa-mir-3143/Upstream/3161368; hsa-mir-10398/Downstream/275276;
Nearest TSS
ENST00000381078/Upstream/2096; ENST00000428555/Downstream/17078;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/48578, chr6-CpG: 109/Downstream/17336
Upstream sequence
acagtgcatagcacattacatacaatagtttatgtaagcttcaactcaactagatgagatgtgtactattgtctccatttcataaaaattatctccattt
Downstream sequence
caccagctaatttttgtatatttagtagagatgggggtttcgccatgttggccaggatggtatcgaactcctgacctcaggtgatccacccgccttggct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate