VISDB Viral Integration Site DataBase

VIS ID

TVIS10012726

Fusion event

HBV-PLXNA4 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1815

Orient

-

Integrated sequence

ACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACC| |ATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACC

Chromosome

chr7

Cytoband

q32.3

Reference genome

Start

End

131873130/132188371 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-1-3p ; hsa-mir-26b-5p ; hsa-mir-6787-3p ; hsa-mir-4267 ; hsa-mir-7157-5p ; hsa-mir-4310 ; hsa-mir-1226-3p ; hsa-mir-498 ; hsa-mir-4709-3p ; hsa-mir-6744-5p ; hsa-mir-561-5p ; hsa-mir-5002-3p ; hsa-mir-93-3p ; hsa-mir-6830-5p ; hsa-mir-6873-3p ; hsa-mir-7110-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-1178-3p ; hsa-mir-4666a-5p ; hsa-mir-3166 ; hsa-mir-4789-3p ; hsa-mir-8485 ; hsa-mir-4666b ; hsa-mir-5011-3p ; hsa-mir-486-3p ; hsa-mir-6817-3p ; hsa-mir-342-3p ; hsa-mir-6852-5p

Nearest miRNA

hsa-mir-10525/Upstream/1310832; hsa-mir-10399/Downstream/846489;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/242634, chr7-CpG: 168/Downstream/387344

Upstream sequence

tatgcctgtctttactttaatctcttaatcccgtcattttcataagctgaggaggatgtatgtcgcctcaggaccctgtgatgattgcattaactgcaca

Downstream sequence

TGAGAAGCCTGTATCTGCATTTAAATGAAGATTTCTCTCTCCCTTCCCCAGCTACCTCCTCCTTAAAGAATTCAGCACCAAAAGTCGAACCCTCTCAGTT