Basic Information
VIS ID
TVIS10012727
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1785
Orient
-
Integrated sequence
CAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTG| |TAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCC
Host Sequence
Chromosome
chr7
Cytoband
q33
Reference genome
GRCh37/hg19
Start
134268110/134583358 (Hg38)
End
134268110/134583358 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10525/Upstream/1292370; hsa-mir-10399/Downstream/623636;
Nearest TSS
ENST00000635602/Upstream/18570; ENST00000443095/Downstream/63450;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/124047, chr7-CpG: 63/Downstream/403010
Nearby gene
AKR1B15(-3518) ; BPGM(+63421) ;
Upstream sequence
TGGCTTGCCTTTTAAGGCAGGCGGTGTTTAGATTTATTATTAGTGAGGTTCAAAGGTGAAACCTAAGGAAATGCTGGACACTTTGAAGGAGGGGCTATCT
Downstream sequence
ATAAAAATTGACCAGTACATGACATGAAAAATTGTACTGACTAGTAATAAGAATGCAAATTAAAATAAGTTTTTTTCACTATCAAACCAACAAAACTTAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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