VISDB Viral Integration Site DataBase

VIS ID

TVIS10012728

Fusion event

HBV-CNTNAP2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|large S protein|

Start

2851

Orient

-

Integrated sequence

ACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCAT| |GGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTC

Chromosome

chr7

Cytoband

q35

Reference genome

Start

End

146780458/147083366 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-218-5p ; hsa-mir-99b-5p ; hsa-mir-4444 ; hsa-mir-6079 ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-6077 ; hsa-mir-7-5p ; hsa-mir-4428 ; hsa-mir-571 ; hsa-mir-8087 ; hsa-mir-7161-5p ; hsa-mir-548u

Nearest miRNA

hsa-mir-10399/Upstream/3700566; hsa-mir-153-2/Downstream/294651;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/966374, chr7-CpG: 33/Downstream/1256036

Nearest cancer related gene

CNTNAP2(TSG, No orient, 0)

Upstream sequence

ATTTATTATTAGTGAGGTTCAAAGGTGAAACCTAAGGAAATGCTGGACACTTTGAAGGAGGGGCTATCTCAGCCAGGGGTCACATGATAGCTGCTAATTG

Downstream sequence

TGTATTTTGCTTCTAGTGATTTGGAGAAGTAGGCAATAATGTCGCTCACCTCTACTAAATGTATATTGTAATGTGTACATTAAATTTAAAATTGTACAAA